Heiko Herwald Selected Research

Necrotizing Fasciitis

1/2018	Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein.
12/2015	Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.
9/2011	Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense.
7/2010	M1 protein from streptococcus pyogenes induces nitric oxide-mediated vascular hyporesponsiveness to phenylephrine: involvement of toll-like receptor activation.
9/2009	Neutrophil-derived hyperresistinemia in severe acute streptococcal infections.
2/2004	M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage.

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Heiko Herwald Research Topics

Disease

22	Infections 01/2019 - 02/2004
15	Sepsis (Septicemia) 08/2021 - 06/2002
12	Inflammation (Inflammations) 01/2019 - 08/2002
11	Edema (Dropsy) 06/2015 - 01/2011
9	Streptococcal Infections (Streptococcal Infection) 11/2012 - 02/2004
8	Lung Injury 01/2019 - 01/2011
7	Septic Shock (Toxic Shock Syndrome) 08/2021 - 09/2008
7	Acute Lung Injury 01/2019 - 06/2011
6	Bacterial Infections (Bacterial Infection) 12/2019 - 08/2003
6	Shock 01/2019 - 10/2009
6	Pneumonia (Pneumonitis) 01/2018 - 01/2011
6	Necrotizing Fasciitis 01/2018 - 02/2004
5	Communicable Diseases (Infectious Diseases) 03/2020 - 08/2007
3	Leptospirosis 01/2019 - 08/2010
3	Cystic Fibrosis (Mucoviscidosis) 01/2018 - 01/2017
3	Thrombosis (Thrombus) 01/2018 - 06/2011
3	Hemolysis 01/2018 - 12/2010
3	Critical Illness (Critically Ill) 02/2016 - 01/2013
2	Wounds and Injuries (Trauma) 01/2020 - 01/2014
2	Burns 01/2019 - 12/2009
2	Endocarditis 01/2018 - 06/2002
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2017 - 01/2016
1	Pancreatitis 08/2021
1	Asthma (Bronchial Asthma) 01/2019
1	Heart Arrest (Cardiac Arrest) 01/2019
1	Pneumococcal Infections 01/2019
1	Soft Tissue Infections 01/2018
1	Bacterial Meningitis 01/2018
1	Gram-Negative Bacterial Infections 01/2018
1	Cellulitis 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	Atherosclerosis 01/2017
1	Reperfusion Injury 01/2017
1	Venous Thrombosis (Deep-Vein Thrombosis) 01/2017
1	Pathologic Processes 10/2015
1	Disseminated Intravascular Coagulation 10/2015
1	Thrombocytopenia (Thrombopenia) 01/2014
1	Respiratory Insufficiency (Respiratory Failure) 01/2013

Drug/Important Bio-Agent (IBA)

23	Proteins (Proteins, Gene)FDA Link 01/2018 - 02/2004
13	human AZU1 proteinIBA 08/2021 - 08/2004
10	CXC ChemokinesIBA 06/2015 - 06/2011
5	BradykininIBA 01/2019 - 11/2008
5	Histones (Histone)IBA 01/2019 - 01/2014
5	Peptides (Polypeptides)IBA 01/2018 - 07/2009
4	Biomarkers (Surrogate Marker)IBA 08/2021 - 08/2010
4	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 06/2011
4	Chemotactic FactorsIBA 01/2019 - 12/2008
3	OsteopontinIBA 01/2019 - 01/2016
3	FibrinIBA 01/2018 - 06/2002
3	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 01/2017
3	KininsIBA 02/2011 - 08/2002
2	Hemostatics (Antihemorrhagics)IBA 01/2019 - 01/2016
2	High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)IBA 12/2018 - 07/2009
2	Deoxyribonucleases (DNase)FDA Link 01/2018 - 01/2017
2	Virulence Factors (Pathogenicity Factors)IBA 01/2018 - 01/2018
2	ResistinIBA 02/2016 - 09/2009
2	CoagulantsIBA 01/2016 - 01/2013
2	ChemokinesIBA 06/2015 - 02/2010
2	Fibrinogen (Factor I)FDA Link 04/2015 - 02/2004
2	Simvastatin (Zocor)FDA LinkGeneric 07/2013 - 06/2011
2	Complement System Proteins (Complement)IBA 12/2010 - 08/2003
2	AnticoagulantsIBA 02/2010 - 09/2007
1	HepcidinsIBA 01/2020
1	IronIBA 01/2020
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 01/2020
1	Local Anti-Infective Agents (Antiseptics)IBA 01/2020
1	Protein Isoforms (Isoforms)IBA 12/2019
1	AntithrombinsIBA 12/2019
1	AllergensIBA 01/2019
1	LipopolysaccharidesIBA 01/2019
1	EndotoxinsIBA 01/2018
1	Cell-Free Nucleic AcidsIBA 01/2018
1	tissue-factor-pathway inhibitor 2 (PP5)IBA 01/2018
1	lipoprotein-associated coagulation inhibitor (TFPI)IBA 01/2018
1	Interleukin-10 (Interleukin 10)IBA 01/2018
1	Lipopolysaccharide ReceptorsIBA 01/2018
1	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2018
1	Immunoglobulins (Immunoglobulin)IBA 01/2018
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	AntigensIBA 01/2018
1	Bacterial Proteins (Bacterial Protein)IBA 01/2018
1	Pharmaceutical PreparationsIBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2017
1	Nucleic AcidsIBA 01/2017
1	LactamsIBA 01/2017
1	QuinolonesIBA 01/2017
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2017
1	EM703IBA 01/2017
1	MacrolidesIBA 01/2017
1	Glycoproteins (Glycoprotein)IBA 01/2016
1	Thrombin FDA Link 10/2015
1	NSC 74859IBA 06/2015
1	Membrane Proteins (Integral Membrane Proteins)IBA 04/2015
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 07/2013
1	GGTI-2133IBA 03/2013
1	TransferasesIBA 03/2013
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2013

Therapy/Procedure

4	Critical Care (Surgical Intensive Care) 12/2018 - 09/2008
1	Therapeutics 03/2020
1	Oral Administration 07/2013